Entry
Name
acireductone dioxygenase (Ni2+-requiring);
ARD;
2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase (ambiguous);
acireductone dioxygenase (ambiguous);
E-2;
1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate- and CO-forming)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one:oxygen oxidoreductase (formate- and CO-forming)
Reaction(IUBMB)
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + formate + CO [RN:
R07363 ]
Reaction(KEGG)
Substrate
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one [CPD:
C15606 ];
O2 [CPD:
C00007 ]
Product
Comment
Requires Ni2+. If iron(II) is bound instead of Ni2+, the reaction catalysed by EC
1.13.11.54 , acireductone dioxygenase [iron(II)-requiring], occurs instead [1]. The enzyme from the bacterium Klebsiella oxytoca (formerly Klebsiella pneumoniae) ATCC strain 8724 is involved in the methionine salvage pathway.
History
EC 1.13.11.53 created 2006
Pathway
ec00270 Cysteine and methionine metabolism
Orthology
K08967 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Genes
CGE : 100754671 100765075(Adi1)
PLEU : 114700277 114702657(Adi1)
PBG : 122480010 122497509(ADI1)
CSUM : 138076821 138080922(ADI1)
BACU : 103007455 103011047(ADI1)
BMUS : 118890347 118892949 118896916 118905857(ADI1)
DLE : 111168004(ADI1) 111181709
PSIU : 116755203 116759180 116762144 116763925(ADI1)
SARA : 101539171 101558778(ADI1)
SFUM : 130033597(ADI1) 130034196
SETR : 126013983 126024456(ADI1)
ETF : 101639374 101652221(ADI1) 101663419
MDO : 100032300(ADI1) 103096762
TVP : 118842957(ADI1) 118848185
ASN : 102381843(ADI1) 102383574
XTR : 100494108 448325(adi1)
MUO : 115459133 115464796(ADI1)
TBEN : 117477650(adi1) 117481432
BPEC : 110155344 110155698
AFIL : 140160780 140162596
PFLL : 139115374 139115906
DSI : Dsimw501_GD14255(Dsim_GD14255)
DMN : 108152158 117186326 117186362 117186365 117186372
CCAT : 101452531 101461090
CLON : 129605996 129612646
CQU : CpipJ_CPIJ007545 CpipJ_CPIJ019272
TMOL : 138135850 138135851
ESIM : 136412701(Adi1) 136412710
EFOR : 136345923(Adi1) 136345924
AGRG : 126747871 126747872
PPYR : 116158744 116166132
PMAC : 106714153 106714154
PPOT : 106099201 106099265
ATRA : 106129789 106129791
CFEL : 113362901 113378018
BROR : 134536630 134546157
PMOO : 119569653 119590061
PPOI : 119096433 119096440 119097351 119097355
RSAN : 119383315 119388078
PTEP : 107451772 107451773
ABRU : 129958065 129959028
PMEO : 129583639 129585231
CEL : CELE_F42F12.4(F42F12.4) CELE_K07E1.1(K07E1.1) CELE_T01D1.4(T01D1.4)
CBR : CBG_00142 CBG_06970 CBG_13458
CRQ : GCK72_004456 GCK72_007810 GCK72_025001
NAI : NECAME_00693 NECAME_03775
HRO : HELRODRAFT_182937 HELRODRAFT_91140
PCAN : 112561366 112573797
LSAX : 138965832 138966456 138966944 138980391
HASI : 137278531 137291461
HCRA : 139474401 139480162
PMAX : 117316541 117321059
LAK : 106152669 106159202 106161531 106178379
ATH : AT2G26400(ARD3) AT4G14710(ATARD2) AT4G14716(ARD1) AT5G43850(ARD4)
ALY : 9301472 9304330 9304332 9315026
CRB : 17876872 17877990 17878417 17890822
CSAT : 104700634 104718952 104718954 104723711 104723713 104725072 104732167 104732170 104747705 104760571 104767223 104771533
EUS : EUTSA_v10003271mg EUTSA_v10026305mg EUTSA_v10026306mg
BRP : 103839226 103848836 103871834
BNA : 106366641 106369190 106372737 106409006 106455045 125577896
BOE : 106313954 106320433 106325213
RSZ : 108828440 108842750 108842751
CPAP : 110815820 110815934
CIC : CICLE_v10005931mg CICLE_v10006993mg
PVY : 116109799 116109800 116109821
MINC : 123210021 123221082 123221085
GHI : 107927794 107928423 107929178 107941618
HSYR : 120134941 120164080 120198722 120218274
DZI : 111280206 111306660 111307352
EGR : 104414755 104423691 104423761 104423771 104432268
RARG : 115743117 115743125 115743132 115750271
GMX : 100306042 100500592 100500632 100812492
GSJ : 114370536 114372097 114403168 114403774
CCAJ : 109806351 109815770
APRC : 113871000 113871332
TPRA : 123914283 123922546
PSAT : 127091219 127092759
VVO : 131611932 131615054 131628581 131628594 131631611
ADU : 107463660 107467053 107467062
AIP : 107617398 107617399 107626512
AHF : 112711752 112711754 112761377 112775449 112776232 140177237
LANG : 109325564 109363382
PCIN : 129287989 129296493 129298322 129320756
QSA : O6P43_003317 O6P43_021528
AANS : 126790356 126791154
RCN : 112200576 112200577 112200578
PMUM : 103323990 103323991
PAVI : 110768657 110768660
PDUL : 117613845 117631699
MDM : 103403944 103416852 103453168
MSYL : 126595929 126607749
PXB : 103935869 103961142 103964742
PCOX : 137731592 137736434
CSAV : 115721731 115722194
MCHA : 111009441 111009656
CMAX : 111473097 111480080 111499393
CMOS : 111447258 111457449 111459925
CPEP : 111790502 111800527 111806754
MEAN : 126669028 126670253
HBR : 110632791 110673232 110673265
MESC : 110611887 110611925
PEU : 105127458 105127467 105130017
PALZ : 118056456 118056466 118061498
JRE : 108989463 109005077 109005080 118349009
CILL : 122278127 122300767
CAVE : 132178866 132179891
TWL : 119983867 119997194 120014466
VVI : 100232920(SIP) 104879260
VRI : 117913816 117914781 117915069
SLY : 101255136 101255431(ARD)
SPEN : 107031252 107031798
SOT : 102577691(ARD) 102599891 102602799 107061612
SSTN : 125851872 125851874 125851893
SDUL : 129883039 129883041 129883699
CANN : 107856555 107857076 107864173
LBB : 132610226 132611024 132611323
NTA : 107774343 107793958 107794003 107794012 107815917 107828443
NSY : 104213236 104220069 104224939
NAU : 109212046 109221219 109229678
INI : 109175899 109175900 109181538
SIND : 105158402 105171299 105171300
OEU : 111371704 111371705 111393695
SSPL : 121759559 121759569 121782944 121784870 121794118
SMIL : 130991384 130991385
SHIS : 125196611 125196612 125219288 125222654
APAN : 127249412 127249417 127250075 127250656
ECAD : 122582183 122582533 122596501
CCAV : 112516594 112519165
DCR : 108200708 108202999 108226372 108226420
CSIN : 114263100 114307313 114315661 114315683
AEW : 130763610 130775033 130775035
DLT : 127799894 127799895 127799896 127810937
SOE : 110800602 110803683 110803694
CQI : 110692471 110692662 110727373 110738094
ATRI : 130825229 130825757
MING : 122073306 122073885 122091478 122091479
TSS : 122642675 122644126 122646613
PSOM : 113304021 113318666 113325428 113337495 113338077 113338127
OSA : 107276095 124459651 124958009(ARD) 4331707(HSFA2D) 4348647(ARD'_4)
DOSA : Os03g0161800 Os03g0161900 Os10g0419400 Os10g0419500
OBR : 102715462 102719518 102719799
OGL : 127766640 127766641 127770454 127785625 127785863
BDI : 100828612 100837759 100838941
TDC : 119283368 119290548 119292822 119316943 119349385 119358074
TAES : 100415845 123066599 123066662 123113665 123130632 123130633 123143994 123144007 123182938 123182941 123190103
TUA : 125516544 125527466 125527481 125531364 125534759
LPER : 127293970 127296825 127298961 127299449 139829878
LRD : 124657426 124701493 124701516 124703487 124703647
SBI : 110431801 8059441 8059853
ZMA : 100216585 103628375 103642691 103643555 103652087
SITA : 101756549 101758523 101761216 101774587
SVS : 117835421 117839236 117840807 117862897
PVIR : 120640572 120647225 120651006 120688935 120690280
PHAI : 112873910 112877802 112900549
PAUA : 133903876 133904137 133907837 133908019 133911646 133916873
MUS : 103986154 103992835 135605592 135609825
ZOF : 121970590 121971608 121975659 121988896 121997841 121999618 122006298 122012770 122014700 122030283
DCT : 110092377 110096467 110106716 110113685
AOF : 109820095 109823326 109831112 109835359 109835361
MSIN : 131248858 131248861
ACAK : 137934041 137942429 137947947
NCOL : 116247622 116248986
CJF : 131034099 131042286 131049234
SMO : SELMODRAFT_155763 SELMODRAFT_230764 SELMODRAFT_26991 SELMODRAFT_270238 SELMODRAFT_37302 SELMODRAFT_407059 SELMODRAFT_410270 SELMODRAFT_416854 SELMODRAFT_420209 SELMODRAFT_421510 SELMODRAFT_425664 SELMODRAFT_445420 SELMODRAFT_6160 SELMODRAFT_75543 SELMODRAFT_85507
PPP : 112277935 112279561 112280915 112287527 112290111 112291272 112291421 112294371
VCN : VOLCADRAFT_106957(adi1)
NCS : NCAS_0F00990(NCAS0F00990)
NDI : NDAI_0H01480(NDAI0H01480)
TPF : TPHA_0H02500(TPHA0H02500)
TBL : TBLA_0A04840(TBLA0A04840)
TDL : TDEL_0H03380(TDEL0H03380)
KAF : KAFR_0K00850(KAFR0K00850)
KNG : KNAG_0E03850(KNAG0E03850)
LBG : 92205530(LODBEIA_P03340)
CAL : CAALFM_C111100WA(CaO19.2306)
ASAU : 88174194(PUMCH_003130)
YLI : 2906238(YALI2_A00223g)
NTE : NEUTE1DRAFT63115(NEUTE1DRAFT_63115)
SMP : 10808112(SMAC4_02277)
PBEL : QC761_708710(ADI1_3)
PPSD : QC762_708710(ADI1_3)
PPSP : QC763_708710(ADI1_3)
PPSA : QC764_708710(ADI1_3)
RTHE : 98121812(VTJ83DRAFT_1051)
FPOA : FPOAC1_002728(ADI1)
TATV : 25780596(TrAtP1_009892)
PLJ : 28888762(PLICBS_009195)
PTKZ : JDV02_005889(ADI1_2)
CDET : 87937348(CDEST_00845)
BFU : BCIN_03g05390(Bcadi1)
PTRR : 6339229(PtrM4_013940)
ADAC : 96088956(ACET3X_008634)
CDEC : 89992150(IAS62_005380)
CTEG : 91992505(I308_105650)
CBAS : 91983394(I312_103349)
CDEP : 91085413(L203_101199)
KMG : 30161433(I203_105808)
KNE : 92183679(IAR55_006421)
KDJ : 28964007(I303_100308)
KBI : 30206542(I302_103443)
KPIN : 30168644(I206_101051)
KSH : 87952418(IL334_000287)
KER : 91102936(V865_004134)
CCAC : CcaHIS019_0603630(ADI1)
HIR : HETIRDRAFT_440456 HETIRDRAFT_460795
CCI : CC1G_11132 CC1G_11133
ABP : AGABI1DRAFT116763(AGABI1DRAFT_116763)
ABV : AGABI2DRAFT195510(AGABI2DRAFT_195510)
MPR : MPER_01262 MPER_05095
MRR : Moror_13588 Moror_16854
MORE : E1B28_005463 E1B28_006535 E1B28_007123 E1B28_008410 E1B28_008448 E1B28_010456(ADI11) E1B28_011987
SCM : SCHCO_02630459(SCHCODRAFT_02630459)
CPUT : CONPUDRAFT_110087 CONPUDRAFT_139338
MLR : MELLADRAFT_39941 MELLADRAFT_73563
FCY : FRACYDRAFT_143530 FRACYDRAFT_224665 FRACYDRAFT_269716
LMA : LMJF_20_0970 LMJF_34_4600
LIF : LINJ_20_0980 LINJ_34_4230
LDO : LDBPK_200980 LDBPK_344230
LMI : LMXM_20_0970 LMXM_33_4600
LMAT : 92512567(LSCM1_02472) 92516379(LSCM1_06439)
LBZ : LBRM_20_4060 LBRM_20_5150
LPAN : LPMP_204190 LPMP_205150
LOI : 92357173(LSCM4_01176) 92362031(LSCM4_06172)
LEIS : 94177707(GH5_02165) 94181353(GH5_06007)
LENR : 94169025(CUR178_01747) 94173061(CUR178_05872)
LEIN : 94185519(JIQ42_01783) 94189342(JIQ42_05720)
PHET : 94288131(JKF63_02011) 94291995(JKF63_05965)
REE : electrica_03692(mtnD)
RTG : NCTC13098_05395(mtnD_2)
CLAP : NCTC11466_01029(mtnD)
METY : MRY16398_41210(mtnD)
SFJ : SAMEA4384070_0975(mtnD)
SOF : NCTC11214_00556(mtnD)
SGRI : SGBXF1_00867(mtnD_1)
PATR : EV46_14760 EV46_17255
PATO : GZ59_29930 GZ59_34990
PCC : PCC21_027930 PCC21_033040
PCV : BCS7_13940 BCS7_16640
PWA : Pecwa_1549 Pecwa_3455
PPAR : A8F97_01350 A8F97_11030
PWS : A7983_00645 A7983_13310
PPOA : BJK05_08870 BJK05_11475
PBRA : B5S52_05195 B5S52_07905
PPUJ : E2566_14180 E2566_16605
PARI : I2D83_05325 I2D83_07780
PVZ : OA04_29750(mtnD_2) OA04_35650(mtnD)
PPOO : LW347_13900 LW347_16705
PACB : M9782_16270 M9782_18900
PARL : PEC302110_25720 PEC302110_30630
PPEU : DUT67_04830 DUT67_07585
CED : LH89_09770 LH89_17465
DFN : CVE23_02610 CVE23_17360
DAQ : DAQ1742_00569(mtnD) DAQ1742_00825 DAQ1742_03467(mtnD)
BNG : EH206_04675 EH206_07215
BIZ : HC231_04940 HC231_07490
TPTY : NCTC11468_02957(mtnD)
XPH : XppCFBP6546_19995(XppCFBP6546P_19995)
XHD : LMG31886_24650(mtnD)
LLZ : LYB30171_01072(mtnD)
PVD : CFBP1590__1921(mtnD)
PPRC : PFLCHA0_c44180(mtnD)
PMUD : NCTC8068_01711(mtnD)
PPUU : PputUW4_03698(mtnD)
PTW : TUM18999_23280(mtnD)
PTAE : NCTC10697_02893(mtnD)
PSWO : SD196_10420 SD196_12385
MSHE : MAALD49_24160(mtnD)
MISZ : MishRS11D_26590(mtnD)
HAAH : HALA3H3_510070(mtnD)
HAAZ : HaloA020_06730(mtnD)
HAXI : HAALTHF_16690n(mtnD)
ALCA : ASALC70_00039(mtnD)
PLG : NCTC10937_01837(mtnD)
AXX : ERS451415_05675(mtnD)
KAI : K32_05360(mtnD_1) K32_34690(mtnD_2)
SCU : SCE1572_09820 SCE1572_50320 SCE1572_51125
LCRE : Pla8534_71770(mtnD)
BAZ : BAMTA208_10325(mtnD)
BSON : S101395_03397(mtnD)
PARG : PspKH34_28370(mtnD)
MHEK : JMUB5695_02279(mtnD)
NFR : ERS450000_02672(mtnD_1) ERS450000_05387(mtnD_2)
NAD : NCTC11293_05801(mtnD)
NWL : NWFMUON74_33790(mtnD)
NSPU : IFM12276_10510(mtnD)
SLE : sle_00880(sle_00880)
SGM : GCM10017557_66590(mtnD)
SBRO : GQF42_30080 GQF42_36645
SGJ : IAG43_22410 IAG43_29680
SXT : KPP03845_101544(mtnD)
SABD : N8I86_09200 N8I86_29680
AAUR : V5P93_002633 V5P93_004088
PRUN : PCC7821_03267(mtnD)
MVAG : D0A34_00920 D0A34_11270
ONI : Osc7112_4525 Osc7112_4979
NON : NOS3756_04520 NOS3756_31050
NLK : NIES25_09910 NIES25_43670
NCW : NIES2107_41070 NIES2107_44650
NOSU : JYQ62_18665 JYQ62_22190
RSIN : B6N60_02681 B6N60_02907
NSPH : BDGGKGIB_01646(mtnD)
CALO : Cal7507_1398 Cal7507_3407
CALN : NIES2098_28240 NIES2098_49800
MDP : NIES3275_01110 NIES3275_69420
TOQ : HCG51_26740 HCG51_27085
TTQ : NIES37_21210 NIES37_23180
ALAX : NIES50_63440 NIES50_65410
NCN : BZZ01_03400 BZZ01_07140
» show all
Taxonomy
Reference
Authors
Wray JW, Abeles RH.
Title
A bacterial enzyme that catalyzes formation of carbon monoxide.
Journal
J Biol Chem 268:21466-9 (1993)
Sequence
Reference
Authors
Wray JW, Abeles RH.
Title
The methionine salvage pathway in Klebsiella pneumoniae and rat liver. Identification and characterization of two novel dioxygenases.
Journal
Reference
Authors
Furfine ES, Abeles RH.
Title
Intermediates in the conversion of 5'-S-methylthioadenosine to methionine in Klebsiella pneumoniae.
Journal
J Biol Chem 263:9598-606 (1988)
Reference
Authors
Dai Y, Wensink PC, Abeles RH
Title
One protein, two enzymes.
Journal
Sequence
Reference
Authors
Mo H, Dai Y, Pochapsky SS, Pochapsky TC.
Title
1H, 13C and 15N NMR assignments for a carbon monoxide generating metalloenzyme from Klebsiella pneumoniae.
Journal
Reference
Authors
Dai Y, Pochapsky TC, Abeles RH
Title
Mechanistic studies of two dioxygenases in the methionine salvage pathway of Klebsiella pneumoniae.
Journal
Sequence
Reference
Authors
Al-Mjeni F, Ju T, Pochapsky TC, Maroney MJ.
Title
XAS investigation of the structure and function of Ni in acireductone dioxygenase.
Journal
Reference
Authors
Pochapsky TC, Pochapsky SS, Ju T, Mo H, Al-Mjeni F, Maroney MJ.
Title
Modeling and experiment yields the structure of acireductone dioxygenase from Klebsiella pneumoniae.
Journal
Sequence
Other DBs
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